You might think that phone call might be unlikely, but as of this week it's built in and is likely happening right now.

I was poking around in the latest version of Sysinternals, and tripped over a new option.  You can now submit any running process in memory directly to Virustotal.  it's a simple right-click in the latest version of Process Explorer.

If that's not just the coolest thing!  If your AV product isn't triggering on a suspect process, you can now query all the AV engines without even having to find or upload the file - - assuming that a file that matches your process even exists - if you're in the midst of a security incident a suspect process might not have a matching file.

Sysinternals: http://technet.microsoft.com/en-us/sysinternals

VirusTotal: https://www.virustotal.com/

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Rob VandenBrink
Metafore